ary Alice Young is a seemingly perfect housewife in a WASP suburban neighborhood who suddenly commits suicide. At her funeral all her friends show up for the wake, all of whom have mysterious secrets they keep from their friends. Then include Lynette Scavo, a former ambitious career woman who gave up her job, at her husband Tom's urging, to be a stay-at-home mom for their four children, three of whom are out of control and rambunctious. Susan Mayer is a divorcée living with her 15-year-old daughter Julie who has a meeting of minds with Mike Delfino, a plumber and new neighbor who's also pursued by Susan's narcissistic rival Edie Britt. Bree Van De Kamp is a stereotypical housewife with an obsessive-compulsive disorder for cleanliness which puts a strain on her long-suffering husband Rex and their two teenage kids, Andrew and Danielle. Gabrielle is a former fashion model married to a wealthy executive to satisfy her obsession for money and luxury items, and who is also having an extramarital affair with their teenage gardener John. Neither housewife is aware of that really goes on underneath each other's life, nor or they are of some terrible secret that Mary Alice's husband Paul and their son Zach are also hiding.

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