hen a commercial flight from Germany lands at Boston's Logan Airport without a single passenger or crew member on board alive, FBI agent Olivia Dunham is assigned to the investigative team. When her partner and lover John Scott suffers severe chemical burns, she seeks help from Dr. Walter Bishop a one-time university professor who experimented in the same field but has now been institutionalized for 17 years. To get his cooperation however, she has to get Bishop's son Peter's cooperation as well. The information they gather leads to Massive Dynamic, a huge multinational founded by someone who once shared laboratory space with Dr. Bishop. Agent Dunham also learns that what happened may have been part of a much larger pattern of strange phenomena.

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