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he Pope has decided once and for all to rid himself of Brother Savonarola by excommunicating him. Cesare travels to Florence to give him one last chance to present himself to the Pope but to no avail. He challenges Savonarola to prove he is right, a challenge the Brother foolishly accepts. In Rome, the Duke of Genoa withdraws his marriage proposal in favor of his brother who is in love with Lucrezia. Juan Borgia's health continues to deteriorate. When he threatens Lucrezia's recently baptized son, she wishes him dead. It is Cesare however who takes action. Meanwhile, Cardinal Della Rovere's plot to poison the Pope is moving forward. Having found his food tester's body in the river, the Pope selects a new tester, Della Rovere's young assassin.

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