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aving failed to eliminate the Borgias, Caterina Sforza moves on to a new plan - uniting several warring families into a confederacy of hatred directed to removing the Borgia Pope. Pope Alexander knows who his enemies are - Cardinals from the same families that Caterina Sforza is approaching - and he decides to purge the Vatican's nest of vipers - the College of Cardinals. Cardinal De Luca, fearing he will find himself on the torturer's rack, accuses the heads of those same great families of plotting against the Pope. One among them however has a plan to get rid of him. As Alexander recovers from the attempt on his life, he decides that his mistress should go away.

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