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ucrezia will soon have to leave for Naples with her new husband, and is upset at having to leave her child behind. She soon develops a plan to rid herself of her principal opponent, but Micheletto proposes patience. He finds a solution to her dilemma. At Forli castle, Caterina Sforza formally proposes a union of the five powerful families against Pope Alexander. In Avignon, Cesare meets King Louis XII of France who wants his marriage to be annulled. Also in Avignon is Machiavelli, who advises Cesare that the King can be bought. Cesare wants an army most of all, but he is also looking for a bride, along with a French title and a dowry. The Pope tries to convince Bianca Gonzaga to return to her husband, but she has news for him. It is soon apparent that she is mad.

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