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oung lawyer Ryan Newman is unemployed, feels a sissy failure, had diabetes and his medication contributes to suicidal tendencies. While waiting for a menial job his bossy sister Kristen is arranging at the hospital where she works, Ryan agrees to mind new neighbor Jenna Mueller's beloved dog Wilfred, only the canine talks to him, even appears like a costumed human. Ryan feels better having someone to mind and even with rude criticism mixed into primordial suggestions to get a life.

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